The Punic tombs of the Maltese islands

This study analyzes the distribution of the Punic tombs found thus far in various parts of the Maltese Islands. It also discusses the main burial methods and customs which the natives of these islands practiced in the Punic Period.peer-reviewe

Exoplanet host star classification: multi-objective optimization of incomplete stellar abundance data

The presence of a planetary companion around its host star has been repeatedly linked with stellar properties, affecting the likelihood of substellar object formation and stability in the protoplanetary disc, thus presenting a key challenge in exoplanet science. Furthermore, abundance and stellar parameter data sets tend to be incomplete, which limits the ability to infer distributional characteristics harnessing the entire data set. This work aims to develop a methodology using machine learning (ML) and multi-objective optimization for reliable imputation for subsequent comparison tests and host star recommendation. It integrates fuzzy clustering for imputation and ML classification of hosts and comparison stars into an evolutionary multi-objective optimization algorithm. We test several candidates for the classification model, starting with a binary classification for giant planet hosts. Upon confirmation that the eXtreme Gradient Boosting algorithm provides the best performance, we interpret the performance of both the imputation and classification modules for binary classification. The model is extended to handle multilabel classification for low-mass planets and planet multiplicity. Constraints on the model’s use and feature/sample selection are given, outlining strengths and limitations. We conclude that the careful use of this technique for host star recommendation will be an asset to future missions and the compilation of necessary target lists

Pape satan aleppe...

Ġabra ta’ poeżiji u proża li tinkludi: Il-Għanja taċ-ċaqliq ta’ A. Buttigieg – Kelb xiħ tal-għassa ta’ A. Cremona – Il-fergħa tas-sagħtar ta’ George Zammit – L-infern tal-midneb! ta’ Karmenu Vassallo – Pape satan aleppe... ta’ Albert M. Cassola.N/

Hepatic VLDL secretion : DGAT1 determines particle size but not particle number, which can be supported entirely by DGAT2

We investigated whether, in view of its activity being expressed on both aspects of the endoplasmic reticulum (ER; dual membrane topology), diacylglycerol acyltransferase 1 (DGAT1) plays a distinctive role in determining the triglyceride (TAG) content of VLDL particles secreted by the liver. Mice in which the DGAT1 gene was specifically ablated in hepatocytes (DGAT1-LKO mice) had the same number of VLDL particles (apoB concentration) in the plasma 1 h after Triton 1339 treatment, but these particles were approximately half the size of VLDL particles secreted by control mice and had a proportionately decreased content of TAG, with normal cholesterol and cholesteryl ester contents. Analyses of purified microsomal fractions prepared from 16 h fasted control and DAGT1-LKO mice showed that the TAG/protein ratio in the ER was significantly lower in the latter. Electron micrographs of these livers showed that those from DGAT1-LKO mice did not show the increased lipid content of the smooth ER shown by control livers. The effects of DGAT1- and DGAT2-specific inhibitors on apoB secretion by HepG2 cells showed that DGAT1 is not indispensable for apoB secretion and demonstrated redundancy in the ability of the two enzymes to support apoB secretion. Therefore, our findings show that DGAT1 is essential for the complete lipidation and maturation of VLDL particles within the lumen of the ER, consistent with its dual topology within the ER membrane. In the mouse, DGAT2 can support apoB secretion (particle number) even when TAG availability for full VLDL lipidation is restricted in the absence of DGAT1